Bidirectional Mendelian randomization study of insulin-related traits and risk of ovarian cancer.

ABSTRACT:

Background

It is well known that the occurrence and development of ovarian cancer are closely related to the patient's weight and various endocrine factors in the body.

Aim

Mendelian randomization (MR) was used to analyze the bidirectional relationship between insulin related characteristics and ovarian cancer.

Methods

The data on insulin related characteristics are from up to 5567 diabetes free patients from 10 studies, mainly including fasting insulin level, insulin secretion rate, peak insulin response, etc. For ovarian cancer, UK Biobank data just updated in 2021 was selected, of which the relevant gene data was from 199741 Europeans. Mendelian randomization method was selected, with inverse variance weighting (IVW) as the main estimation, while MR Pleiotropy, MR

SUBMITTER: Wang X 

PROVIDER: S-EPMC10014907 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature