Polarity and mixed-mode oscillations may underlie different patterns of cellular migration.

ABSTRACT: In mesenchymal cell motility, several migration patterns have been observed, including directional, exploratory and stationary. Two key members of the Rho-family of GTPases, Rac and Rho, along with an adaptor protein called paxillin, have been particularly implicated in the formation of such migration patterns and in regulating adhesion dynamics. Together, they form a key regulatory network that involves the mutual inhibition exerted by Rac and Rho on each other and the promotion of Rac activation by phosphorylated paxillin. Although this interaction is sufficient in generating wave-pinning that underscores cellular polarization comprised of cellular front (high active Rac) and back (high active Rho), it remains unclear how they interact collectively to induce other modes of migration dete

SUBMITTER: Plazen L 

PROVIDER: S-EPMC10014943 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature