The roles of bone remodeling in normal hematopoiesis and age-related hematological malignancies.

ABSTRACT: Prior research establishing that bone interacts in coordination with the bone marrow microenvironment (BMME) to regulate hematopoietic homeostasis was largely based on analyses of individual bone-associated cell populations. Recent advances in intravital imaging has suggested that the expansion of hematopoietic stem cells (HSCs) and acute myeloid leukemia cells is restricted to bone marrow microdomains during a distinct stage of bone remodeling. These findings indicate that dynamic bone remodeling likely imposes additional heterogeneity within the BMME to yield differential clonal responses. A holistic understanding of the role of bone remodeling in regulating the stem cell niche and how these interactions are altered in age-related hematological malignancies will be critical to the develo

SUBMITTER: Zhang H 

PROVIDER: S-EPMC10014945 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature