A three-plasma miRNA panel predicts the risk of colorectal cancer: a community-based nested case‒control study.

ABSTRACT: Circulating microRNAs (miRNAs) have been considered potential markers for the early detection of malignant colorectal cancer (CRC). We aimed to identify a group of miRNAs for the early detection of CRC and assess their predictive ability in a community-based population in China. A nested case‒control study consisting of 97 incident colorectal cancer cases and 103 frequency-matched healthy controls was conducted. The data were randomly assigned into a training set (60%) and a test set (40%). We selected and detected 10 kinds of miRNAs in plasma samples. Multivariate logistic regression analysis was used to identify miRNAs associated with colorectal cancer risk in the training set and test set. Then, we evaluated the predictive ability of the identified miRNAs by the receiver operating chara

SUBMITTER: Liu J 

PROVIDER: S-EPMC10014991 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature