UNC-43/CaMKII-triggered anterograde signals recruit GABA_ARs to mediate inhibitory synaptic transmission and plasticity at C. elegans NMJs.

ABSTRACT: Disturbed inhibitory synaptic transmission has functional impacts on neurodevelopmental and psychiatric disorders. An essential mechanism for modulating inhibitory synaptic transmission is alteration of the postsynaptic abundance of GABA_ARs, which are stabilized by postsynaptic scaffold proteins and recruited by presynaptic signals. However, how GABAergic neurons trigger signals to transsynaptically recruit GABA_ARs remains elusive. Here, we show that UNC-43/CaMKII functions at GABAergic neurons to recruit GABA_ARs and modulate inhibitory synaptic transmission at C. elegans neuromuscular junctions. We demonstrate that UNC-43 promotes presynaptic MADD-4B/Punctin secretion and NRX-1α/Neurexin surface delivery. Together, MADD-4B and NRX-1α recruit postsynaptic N

SUBMITTER: Hao Y 

PROVIDER: S-EPMC10015018 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature