Noninvasive electromyometrial imaging of human uterine maturation during term labor.

ABSTRACT: Electromyometrial imaging (EMMI) was recently developed to image the three-dimensional (3D) uterine electrical activation during contractions noninvasively and accurately in sheep. Herein we describe the development and application of a human EMMI system to image and evaluate 3D uterine electrical activation patterns at high spatial and temporal resolution during human term labor. We demonstrate the successful integration of the human EMMI system during subjects' clinical visits to generate noninvasively the uterine surface electrical potential maps, electrograms, and activation sequence through an inverse solution using up to 192 electrodes distributed around the abdomen surface. Quantitative indices, including the uterine activation curve, are developed and defined to characterize uterin

SUBMITTER: Wang H 

PROVIDER: S-EPMC10015052 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature