SIRT7 orchestrates melanoma progression by simultaneously promoting cell survival and immune evasion via UPR activation.

ABSTRACT: Melanoma is the most lethal type of skin cancer, originating from the malignant transformation of melanocyte. While the development of targeted therapy and immunotherapy has gained revolutionary advances in potentiating the therapeutic effect, the prognosis of patients with melanoma is still suboptimal. During tumor progression, melanoma frequently encounters stress from both endogenous and exogenous sources in tumor microenvironment. SIRT7 is a nuclear-localized deacetylase of which the activity is highly dependent on intracellular nicotinamide adenine dinucleotide (NAD⁺), with versatile biological functions in maintaining cell homeostasis. Nevertheless, whether SIRT7 regulates tumor cell biology and tumor immunology in melanoma under stressful tumor microenvironment remains el

SUBMITTER: Yi X 

PROVIDER: S-EPMC10015075 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature