Evolutionary trend of bovine β-defensin proteins toward functionality prediction: A domain-based bioinformatics study.

ABSTRACT: Defensins are small cationic cysteine-rich and amphipathic peptides that form of three-dimensional β-strand structure connected by disulfide bonds. Defensins form key elements of the innate immune system of multicellular organisms. They not only possess broad-spectrum antimicrobial activity but also have diverse roles, including cell signaling, ion channel agitation, toxic functions, and enzyme inhibitor activities in various animals. Although the role of β-defensins in immune responses against infectious agents and reproduction could be significant, inadequate genomic information is available to explain the whole β-defensin repertoire in cattle. No domain or motif-based functional analyses have been previously reported. In addition, how do defensins possess this magnitude of functions in

SUBMITTER: Islam S 

PROVIDER: S-EPMC10015202 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature