Using inbreeding to test the contribution of non-additive genetic effects to additive genetic variance: a case study in Drosophila serrata.

ABSTRACT: Additive genetic variance, V_A, is the key parameter for predicting adaptive and neutral phenotypic evolution. Changes in demography (e.g. increased close-relative inbreeding) can alter V_A, but how they do so depends on the (typically unknown) gene action and allele frequencies across many loci. For example, V_A increases proportionally with the inbreeding coefficient when allelic effects are additive, but smaller (or larger) increases can occur when allele frequencies are unequal at causal loci with dominance effects. Here, we describe an experimental approach to assess the potential for dominance effects to deflate V_A under inbreeding. Applying a powerful paired pedigree design in Drosophila serrata, we measured

SUBMITTER: Dugand RJ 

PROVIDER: S-EPMC10015326 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature