Cerebrospinal fluid YKL-40 level evolution is associated with autoimmune encephalitis remission.

ABSTRACT:

Objective

Because of its heterogeneity in clinical presentation and course, predicting autoimmune encephalitis (AIE) evolution remains challenging. Hence, our aim was to explore the correlation of several biomarkers with the clinical course of disease.

Methods

Thirty-seven cases of AIE were selected retrospectively and divided into active (N = 9), improved (N = 12) and remission (N = 16) AIE according to their disease evolution. Nine proteins were tested in both serum and cerebrospinal fluid (CSF) at diagnosis (T0) and during the follow-up (T1), in particular activated MMP-9 (MMP-9A) and YKL-40 (or chitinase 3-like 1).

Results

From diagnosis to revaluation, AIE remission was associated with decreased YKL-40 and MMP-9A levels in the CSF, and with d

SUBMITTER: Dorcet G 

PROVIDER: S-EPMC10015376 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature