Post-translational modifications confer amphotericin B resistance in Candida krusei isolated from a neutropenic patient.

ABSTRACT: Neutropenia is a common complication in the treatment of hematological diseases and the most common predisposing factor for invasion by fungi, such as Candida krusei. Recent studies have shown that C. krusei, a life-threatening pathogen, has developed resistance to amphotericin B (AMB). However, the mechanisms that led to the rapid emergence of this AMB-resistant phenotype are unclear. In this study, we found the sensitivity for AMB could be promoted by inhibiting histone acyltransferase activity and western blot analysis revealed differences in the succinylation levels of C. krusei isolated from immunocompromised patients and of the corresponding AMB-resistant mutant. By comparative succinyl-proteome analysis, we identified a total of 383 differentially expressed succ

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10015421 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature