Effect of Antigen Structure in Subunit Vaccine Nanoparticles on Humoral Immune Responses.

ABSTRACT: Subunit vaccines offer numerous attractive features, including good safety profiles and well-defined components with highly characterized properties because they do not contain whole pathogens. However, vaccine platforms based on one or few selected antigens are often poorly immunogenic. Several advances have been made in improving the effectiveness of subunit vaccines, including nanoparticle formulation and/or co-administration with adjuvants. Desolvation of antigens into nanoparticles is one approach that has been successful in eliciting protective immune responses. Despite this advance, damage to the antigen structure by desolvation can compromise the recognition of conformational antigens by B cells and the subsequent humoral response. Here, we used ovalbumin as a model antigen to demo

SUBMITTER: Park J 

PROVIDER: S-EPMC10015428 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature