Controlled Release of H₂S from Biomimetic Silk Fibroin-PLGA Multilayer Electrospun Scaffolds.

ABSTRACT: The possibility of incorporating H₂S slow-release donors inside biomimetic scaffolds can pave the way to new approaches in the field of tissue regeneration and anti-inflammatory treatment. In the present work, GYY4137, an easy-to-handle commercially available Lawesson's reagent derivative, has been successfully incorporated inside biomimetic silk fibroin-based electrospun scaffolds. Due to the instability of GYY4137 in the solvent needed to prepare silk fibroin solutions (formic acid), the electrospinning of the donor together with the silk fibroin turned out to be impossible. Therefore, a multilayer structure was realized, consisting of a PLGA mat containing GYY4137 sandwiched between two silk fibroin nanofibrous layers. Before their use in the multilayer scaffold, the silk fib

SUBMITTER: Liguori A 

PROVIDER: S-EPMC10015463 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature