A Mitochondrial DNA Haplogroup Defines Patterns of Five-Year Cognitive Change.

ABSTRACT:

Background

Mitochondrial DNA (mtDNA) may play a role in Alzheimer's disease (AD) and cognitive decline. A particular haplogroup of mtDNA, haplogroup J, has been observed more commonly in patients with AD than in cognitively normal controls.

Objective

We used two mtDNA haplogroups, H and J, to predict change in cognitive performance over five years. We hypothesized that haplogroup J carriers would show less cognitive resilience.

Methods

We analyzed data from 140 cognitively normal older adults who participated in the University of Kansas Alzheimer's Disease Research Center clinical cohort between 2011 and 2020. We used factor analysis to create three composite scores (verbal memory, attention, and executive function) from 11 individual cognitive tests. We performed lat

SUBMITTER: Watts A 

PROVIDER: S-EPMC10015634 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature