Erastin inhibits porcine epidemic diarrhea virus replication in Vero cells.

ABSTRACT:

Background

Porcine epidemic diarrhea virus (PEDV), an intestinal pathogenic coronavirus, has caused significant economic losses to the swine industry worldwide. At present, there are several treatment methods, but there is still a lack of clinically effective targeted drugs, new antiviral mechanisms and drugs need to be explored.

Methods

In this study, we established a model of erastin versus ferrostatin-1 treatment of Vero cells, and then detected virus proliferation and gene expression by RT-qPCR through PEDV infection experiments.

Results

We demonstrated for the first time that erastin significantly inhibited the replication of PEDV upon entry into cells; Vero treated with erastin significantly regulated the expression of three genes, NRF2, ACSL4 and

SUBMITTER: Zhang H 

PROVIDER: S-EPMC10015705 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature