The expression, immune infiltration, prognosis, and experimental validation of OSBPL family genes in liver cancer.

ABSTRACT:

Background

Liver cancer is the third most deadly malignant tumor in the world with poor prognosis and lacks early diagnostic markers. It is urgent need to explore new biomarkers and prognostic factors. The oxysterol-binding protein-like family proteins (OSBPLs) are essential mediators of lipid transportation and cholesterol balancing which has been reported to participate in cancer progression. So far, the expression, immune infiltration, and prognosis of OSBPLs have not been elucidated in liver cancer.

Methods

The differential expressions of OSBPLs between liver tumor and normal tissues were assessed by analyzing RNA-seq data from TCGA and protein data from CPTAC, respectively. Subsequently, genetic variations, potential functional enrichment analysis, and immune cell infil

SUBMITTER: Tian K 

PROVIDER: S-EPMC10015719 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature