Vitamin D status and risk of rheumatoid arthritis: systematic review and meta-analysis.

ABSTRACT:

Background

Vitamin D is important for immunomodulation and may play a role in autoimmune diseases. Studies have reported a high prevalence of vitamin D deficiency in rheumatoid arthritis (RA) patients, and vitamin D status, assessed by circulating 25-hydroxyvitamin D [25(OH)D] concentration, is inversely associated with RA disease activity. However, it is unclear whether vitamin D deficiency increases the risk of later developing RA. We conducted a systematic review and meta-analysis of pre-diagnostic 25(OH)D concentrations and risk of RA.

Methods

Medline and Embase databases were searched in December 2021 using various keywords for 'vitamin D', 'rheumatoid arthritis', and 'prospective study'. Publications identified from the search were screened for eligibility, studies wer

SUBMITTER: Clasen JL 

PROVIDER: S-EPMC10015722 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature