In vivo Sealing of Fetoscopy-Induced Fetal Membrane Defects by Mussel Glue.

ABSTRACT:

Introduction

The benefits of fetal surgery are impaired by the high incidence of iatrogenic preterm prelabor rupture of the fetal membranes (iPPROM), for which chorioamniotic separation has been suggested as a potential initiator. Despite the urgent need to prevent iPPROM by sealing the fetoscopic puncture site after intervention, no approach has been clinically translated.

Methods

A mussel-inspired biomimetic glue was tested in an ovine fetal membrane (FM) defect model. The gelation time of mussel glue (MG) was first optimized to make it technically compatible with fetal surgery. Then, the biomaterial was loaded in polytetrafluoroethylene-coated nitinol umbrella-shaped receptors and applied on ovine FM defects (N = 10) created with a 10 French trocar. Its sealing performanc

SUBMITTER: Avilla-Royo E 

PROVIDER: S-EPMC10015749 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature