Microglial Characterization in Transient Human Neurodevelopmental Structures.

ABSTRACT: Human neurodevelopment is characterized by the appearance, development, and disappearance or transformation of various transient structures that underlie the establishment of connectivity within and between future cortical and subcortical areas. Examples of transient structures in the forebrain (among many others) include the subpial granular layer and the subplate zone. We have previously characterized the precise spatiotemporal dynamics of microglia in the human telencephalon. Here, we describe the diversity of microglial morphologies in the subpial granular layer and the subplate zone. Where possible, we couple the predominant morphological phenotype with functional characterizations to infer tentative roles for microglia in a changing neurodevelopmental landscape. We interpret these fi

SUBMITTER: Menassa DA 

PROVIDER: S-EPMC10015752 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature