A proteasomal β5 subunit of Haemonchus contortus with a role in the growth, development and life span.

ABSTRACT:

Background

The proteasome in eukaryotic cells can degrade a variety of proteins and plays an important role in regulating the cell cycle, cell survival and apoptosis. The proteasome receives much attention as a potential chemotherapeutic target for treatment of a variety of infectious parasitic diseases, but few studies of proteasomes have been done on parasitic nematodes.

Methods

A proteasomal β5 subunit encoding gene (named Hc-pbs-5) and its inferred product (Hc-PBS-5) in Haemonchus contortus were identified and characterized in this study. Then, the transcriptional profiles and anatomical expression were studied using an integrated molecular approach. Finally, a specific proteasome inhibitor bortezomib (BTZ), together with RNA interference (RNAi), was employed to assess t

SUBMITTER: He L 

PROVIDER: S-EPMC10015785 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature