Only SF3B1 mutation involving K700E independently predicts overall survival in myelodysplastic syndromes.

ABSTRACT:

Background

SF3B1 mutations (SF3B1^mut ) in myelodysplastic syndromes (MDS) frequently involve codon K700E and have a favorable prognosis. The prognostic effect of non-K700E SF3B1^mut is uncertain.

Methods

The authors analyzed the clinicopathological features and outcomes of a single-institution series of 94 treatment-naive SF3B1^mut MDS patients (18%) and 415 treatment-naive SF3B1^wt MDS patients and explored the differences between K700E and non-K700E SF3B1^mut MDS.

Results

Fifty-five patients (59%) carried K700E. Recurrent non-K700E mutations (39 [41%]) included R625, H662, and K666. Compared with SF3B1^mut K700E patients, non-K700E patients had a lower median absolute neutrophil count (1.8 vs 2.4; P = .005

SUBMITTER: Kanagal-Shamanna R 

PROVIDER: S-EPMC10015977 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature