Advances in Liver Transplantation: where are we in the pursuit of transplantation tolerance?

ABSTRACT: Liver transplantation is the ultimate treatment option for end-stage liver disease. Breakthroughs in surgical practice and immunosuppression have seen considerable advancements in survival after transplantation. However, the intricate management of immunosuppressive regimens, balancing desired immunological quiescence while minimizing toxicity has proven challenging. Diminishing improvements in long-term morbidity and mortality have been inextricably linked with the protracted use of these medications. As such, there is now enormous interest to devise protocols that will allow us to minimize or completely withdraw immunosuppressants after transplantation. Immunosuppression withdrawal trials have proved the reality of tolerance following liver transplantation, however, without intervention

SUBMITTER: Safinia N 

PROVIDER: S-EPMC10015994 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature