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Three new coordination geometries of homoleptic Zn complexes of curcuminoids and their high antiproliferative potential.

ABSTRACT: To our previously reported first crystal structure of a homoleptic zinc curcuminoid complex with square pyramidal geometry, we add herein three new geometries of homoleptic type complexes i.e. octahedral, trigonal-pyramidal, and trigonal-bipyramidal. Octahedral geometry was observed in the new pseudo-polymorph of the DAC-Zn complex resulting from crystallization in DMF, while square-pyramidal geometry was obtained in DMSO. Improving crystallinity involved suppressing the phenolic interactions by etherification and esterification. The complete characterization of these complexes was carried out using SCXRD, IR, MS, EA, liquid, and solid-state NMR. Moreover, the cytotoxic activity of all complexes was evaluated. The IC50 values for the DiMeOC-Zn (7) complex were 8 or 22 times higher than for cisplatin in the U251 and HCT-15 cell lines, indicating a high antiproliferative and therapeutic potential.

SUBMITTER: Meza-Morales W 

PROVIDER: S-EPMC10016078 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Three new coordination geometries of homoleptic Zn complexes of curcuminoids and their high antiproliferative potential.

Meza-Morales William W   Alvarez-Ricardo Yair Y   Obregón-Mendoza Marco A MA   Arenaza-Corona Antonino A   Ramírez-Apan María Teresa MT   Toscano Rubén A RA   Poveda-Jaramillo Juan Carlos JC   Enríquez Raúl G RG  

RSC advances 20230315 13

To our previously reported first crystal structure of a homoleptic zinc curcuminoid complex with square pyramidal geometry, we add herein three new geometries of homoleptic type complexes <i>i.e.</i> octahedral, trigonal-pyramidal, and trigonal-bipyramidal. Octahedral geometry was observed in the new pseudo-polymorph of the DAC-Zn complex resulting from crystallization in DMF, while square-pyramidal geometry was obtained in DMSO. Improving crystallinity involved suppressing the phenolic interact  ...[more]

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