Acid-induced nitrite reduction of nonheme iron(ii)-nitrite: mimicking biological Fe-NiR reactions.

ABSTRACT: Nitrite reductase (NiR) catalyzes nitrite (NO₂ ^-) to nitric oxide (NO) transformation in the presence of an acid (H⁺ ions/pH) and serves as a critical step in NO biosynthesis. In addition to the NiR enzyme, NO synthases (NOSs) participate in NO production. The chemistry involved in the catalytic reduction of NO₂ ^-, in the presence of H⁺, generates NO with a H₂O molecule utilizing two H⁺ + one electron from cytochromes and is believed to be affected by the pH. Here, to understand the effect of H⁺ ions on NO₂ ^- reduction, we report the acid-induced NO₂ ^- reduction chemistry of a nonheme Fe^II-nitrito complex, [(12TMC)Fe^II(NO₂

SUBMITTER: Kulbir 

PROVIDER: S-EPMC10016336 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature