Experimental and theoretical elucidation of SPAAC kinetics for strained alkyne-containing cycloparaphenylenes.

ABSTRACT: Tuning strained alkyne reactivity via organic synthesis has evolved into a burgeoning field of study largely focused on cyclooctyne, wherein physical organic chemistry helps guide rational molecular design to produce molecules with intriguing properties. Concurrent research in the field of carbon nanomaterials has produced new types of strained alkyne macrocycles, such as cycloparaphenyleneacetylenes, that possess uniquely curved aromatic π systems but hover on the edge of stability. In 2018, we introduced a strained alkyne scaffold that marries the synthetic accessibility and stability of cyclooctyne with the curved π system of carbon nanomaterials. These molecules are strained alkyne-containing cycloparaphenylenes (or [n+1]CPPs), which have been shown to possess size-depend

SUBMITTER: Fehr JM 

PROVIDER: S-EPMC10016359 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature