Cerebellar Functional Dysconnectivity in Drug-Naive Patients With First-Episode Schizophrenia.

ABSTRACT: Cerebellar functional dysconnectivity has long been implicated in schizophrenia. However, the detailed dysconnectivity pattern and its underlying biological mechanisms have not been well-charted. This study aimed to conduct an in-depth characterization of cerebellar dysconnectivity maps in early schizophrenia. Resting-state fMRI data were processed from 196 drug-naïve patients with first-episode schizophrenia and 167 demographically matched healthy controls. The cerebellum was parcellated into nine functional systems based on a state-of-the-art atlas, and seed-based connectivity for each cerebellar system was examined. The observed connectivity alterations were further associated with schizophrenia risk gene expressions using data from the Allen Human Brain Atlas. Overall, we observed sign

SUBMITTER: Cao H 

PROVIDER: S-EPMC10016395 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature