Association Between Human Blood Metabolome and the Risk of Psychiatric Disorders.

ABSTRACT:

Background and hypothesis

To identify promising drug targets for psychiatric disorders, we applied Mendelian randomization (MR) design to systematically screen blood metabolome for potential mediators of psychiatric disorders and further predict target-mediated side effects.

Study design

We selected 92 unique blood metabolites from 3 metabolome genome-wide association studies (GWASs) with totally 147 827 participants. Summary statistics for bipolar disorder (BIP), attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), major depressive disorder (MDD), schizophrenia (SCZ), panic disorder (PD), autistic spectrum disorder (ASD), and anorexia nervosa (AN) originated from the Psychiatric Genomics Consortium, involving 1 143 340 participants. Mendelia

SUBMITTER: Jia Y 

PROVIDER: S-EPMC10016401 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature