Speech Illusions in People at Clinical High Risk for Psychosis Linked to Clinical Outcome.

ABSTRACT:

Background and hypothesis

Around 20% of people at clinical high risk (CHR) for psychosis later develop a psychotic disorder, but it is difficult to predict who this will be. We assessed the incidence of hearing speech (termed speech illusions [SIs]) in noise in CHR participants and examined whether this was associated with adverse clinical outcomes.

Study design

At baseline, 344 CHR participants and 67 healthy controls were presented with a computerized white noise task and asked whether they heard speech, and whether speech was neutral, affective, or whether they were uncertain about its valence. After 2 years, we assessed whether participants transitioned to psychosis, or remitted from the CHR state, and their functioning.

Study results

CHR participants had a lower

SUBMITTER: Hird EJ 

PROVIDER: S-EPMC10016413 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature