Neuronal excitability as a regulator of circuit remodeling.

ABSTRACT: Postnatal remodeling of neuronal connectivity shapes mature nervous systems.^1,2,3 The pruning of exuberant connections involves cell-autonomous and non-cell-autonomous mechanisms, such as neuronal activity. Indeed, experience-dependent competition sculpts various excitatory neuronal circuits.^4,5,6,7,8,9 Moreover, activity has been shown to regulate growth cone motility and the stability of neurites and synaptic connections.^{10,11,12,13,14} However, whether inhibitory activity influences the remodeling of neuronal connecti

SUBMITTER: Mayseless O 

PROVIDER: S-EPMC10017263 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature