High frame rate deformation analysis of knee cartilage by spiral dualMRI and relaxation mapping.

ABSTRACT:

Purpose

Daily activities including walking impose high-frequency cyclic forces on cartilage and repetitive compressive deformation. Analyzing cartilage deformation during walking would provide spatial maps of displacement and strain and enable viscoelastic characterization, which may serve as imaging biomarkers for early cartilage degeneration when the damage is still reversible. However, the time-dependent biomechanics of cartilage is not well described, and how defects in the joint impact the viscoelastic response is unclear.

Methods

We used spiral acquisition with displacement-encoding MRI to quantify displacement and strain maps at a high frame rate (25 frames/s) in tibiofemoral joints. We also employed relaxometry methods (T₁ , T_1ρ , T₂

SUBMITTER: Lee W 

PROVIDER: S-EPMC10017275 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature