Effects of selenium deficiency on biological results of X-ray and carbon-ion beam irradiation in mice.

ABSTRACT: The impact of radiation-induced hydrogen peroxide (H₂O₂) on the biological effects of X-rays and carbon-ion beams was investigated using a selenium-deficient (SeD) mouse model. Selenium is the active center of glutathione peroxidase (GSH-Px), and SeD mice lack the ability to degrade H₂O₂. Male and female SeD mice were prepared by feeding a torula yeast-based SeD diet and ultrapure water. Thirty-day survival rates after whole-body irradiation, radiation-induced leg contracture, and MRI-based redox imaging of the brain were assessed and compared between SeD and normal mice. Thirty-day lethality after whole-body 5.6 Gy irradiation with X-rays or carbon-ion beams was higher in the SeD mice than in the normal mice, while SeD did not give the notable d

SUBMITTER: Ueno M 

PROVIDER: S-EPMC10017320 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature