DNA-Polyelectrolyte Composite Responsive Microparticles for Versatile Chemotherapeutics Cleaning.

ABSTRACT: Drug therapy is among the most widely used methods in disease treatment. However, there remains a trade-off problem between drug dosage and toxicity. Blood purification by adsorption of excessive drugs during clinical treatment could be a solution for enhancing therapeutic efficacy while maintaining normal body function. Here, inspired by the intrinsic action mechanism of chemotherapeutic agents in targeting DNA in the cell nucleus, we present DNA-polyelectrolyte composite responsive microparticles for chemotherapeutics cleaning. The presence of DNA in the microparticles enabled the adsorption of multiple common chemotherapy drugs. Moreover, the microparticles are endowed with a porous structure and a photothermal-responsive ability, both of which contribute to improved adsorption by enhan

SUBMITTER: Wang C 

PROVIDER: S-EPMC10017331 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature