Consequences of Shigella infection in young children: a systematic review.

ABSTRACT:

Objectives

We conducted a systematic review of the longitudinal consequences of Shigella infection in children to inform the value proposition for an effective vaccine.

Methods

We searched PubMed and Embase for studies published from January 01, 1980 to December 12, 2022 and conducted in low- and middle-income countries that included longitudinal follow-up after Shigella detection among children aged <5 years, irrespective of language. We collected data on all outcomes subsequent to Shigella detection, except mortality.

Results

Of 2627 papers identified, 52 met inclusion criteria. The median sample size of children aged <5 years was 66 (range 5-2172). Data were collected in 20 countries; 56% (n = 29) of the publications included Bangladesh. The most common outcomes re

SUBMITTER: Libby TE 

PROVIDER: S-EPMC10017352 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature