Sex differences in childhood maltreatment, inflammation, and adulthood depression: A network analysis.

ABSTRACT:

Background

Efforts to improve treatment for adults with major depression (MD) and childhood maltreatment (CM) have identified inflammation as a potential target to improve health. Network models have emerged as a new way to understand the relationship between depressive symptoms and inflammation. However, none have accounted for the role of childhood maltreatment in the link between depressive symptoms and inflammation, or sex differences commonly found in these constructs.

Methods

Data from two waves of the Midlife Development in the United States study were used in this study (N = 1917). The Center for Epidemiological Studies Depression (CES-D) scale and Childhood Trauma Questionnaire, and six inflammation markers served as nodes in an undirected psychometric network analy

SUBMITTER: O'Shields JD 

PROVIDER: S-EPMC10017358 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature