Plasma metabolites associated with cognitive function across race/ethnicities affirming the importance of healthy nutrition.

ABSTRACT:

Introduction

We studied the replication and generalization of previously identified metabolites potentially associated with global cognitive function in multiple race/ethnicities and assessed the contribution of diet to these associations.

Methods

We tested metabolite-cognitive function associations in U.S.A. Hispanic/Latino adults (n = 2222) from the Community Health Study/ Study of Latinos (HCHS/SOL) and in European (n = 1365) and African (n = 478) Americans from the Atherosclerosis Risk In Communities (ARIC) Study. We applied Mendelian Randomization (MR) analyses to assess causal associations between the metabolites and cognitive function and between Mediterranean diet and cognitive function.

Results

Six metabolites were consistently associated with lower global co

SUBMITTER: Granot-Hershkovitz E 

PROVIDER: S-EPMC10017373 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature