Mechanisms of spontaneous Ca²⁺ release-mediated arrhythmia in a novel 3D human atrial myocyte model: II. Ca²⁺ -handling protein variation.

ABSTRACT: Disruption of the transverse-axial tubule system (TATS) in diseases such as heart failure and atrial fibrillation occurs in combination with changes in the expression and distribution of key Ca²⁺ -handling proteins. Together this ultrastructural and ionic remodelling is associated with aberrant Ca²⁺ cycling and electrophysiological instabilities that underlie arrhythmic activity. However, due to the concurrent changes in TATs and Ca²⁺ -handling protein expression and localization that occur in disease it is difficult to distinguish their individual contributions to the arrhythmogenic state. To investigate this, we applied our novel 3D human atrial myocyte model with spatially detailed Ca²⁺ diffusion and TATS to investigate the isolated and intera

SUBMITTER: Zhang X 

PROVIDER: S-EPMC10017376 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature