Hepatocellular carcinoma subtypes based on metabolic pathways reveals potential therapeutic targets.

ABSTRACT:

Introduction

Hepatocellular carcinoma (HCC) is an aggressive malignancy with steadily increasing incidence rates worldwide and poor therapeutic outcomes. Studies show that metabolic reprogramming plays a key role in tumor genesis and progression. In this study, we analyzed the metabolic heterogeneity of epithelial cells in the HCC and screened for potential biomarkers.

Methods

The hepatic single-cell RNA sequencing (scRNA-seq) datasets of HCC patients and healthy controls were obtained from the Gene Expression Omnibus (GEO) database. Based on data intergration and measurement of differences among groups, the metabolic epithelial cell subpopulations were identified. The single-cell metabolic pathway was analyzed and the myeloid subpopulations were identified. Cell-cell intera

SUBMITTER: He Z 

PROVIDER: S-EPMC10017446 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature