Prediction of outcomes in patients with local recurrent nasopharyngeal carcinoma: development and validation of a four-factor prognostic model integrating baseline characteristics and [¹⁸F]FDG PET/CT parameters.

ABSTRACT:

Objectives

To investigate the prognostic value of [¹⁸F]FDG PET/CT parameters in local recurrent nasopharyngeal carcinoma (lrNPC) and establish a prognostic tool for lrNPC patients based on these [¹⁸F]FDG PET/CT parameters.

Methods

A total of 358 lrNPC patients seen from 2010 to 2019 at Sun Yat-sen University Cancer Center with complete baseline characteristics and [¹⁸F]FDG PET/CT data were retrospectively analyzed. Maximal standardized uptake value (SUVmax), SUVmean, SUVpeak, metabolic tumor volume (MTV), total lesion glycolysis (TLG), and heterogeneity index (HI) for recurrent nasopharynx tumors were included. Cox regression analysis was performed to select candidate variables. Subsequently, a nomogram for predicting overall survival (OS) fo

SUBMITTER: Dongxiang W 

PROVIDER: S-EPMC10017585 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature