Sleep duration, daytime napping, and risk of peripheral artery disease: multinational cohort and Mendelian randomization studies.

ABSTRACT:

Aims

Sleep duration has been associated with cardiovascular disease, however the effect of sleep on peripheral artery disease (PAD) specifically remains unestablished. We conducted observational and Mendelian randomization (MR) analyses to assess the associations of sleep duration and daytime napping with PAD risk.

Methods and results

Sleep traits were assessed for associations with incident PAD using cohort analysis among 53 416 Swedish adults. Replicated was sought in a case-control study of 28 123 PAD cases and 128 459 controls from the veterans affairs Million Veteran Program (MVP) and a cohort study of 452 028 individuals from the UK Biobank study (UKB). Two-sample Mendelian randomization (MR) was used for casual inference-based analyses of sleep-related traits and PAD

SUBMITTER: Yuan S 

PROVIDER: S-EPMC10017627 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature