Lung shrinking assessment on HRCT with elastic registration technique for monitoring idiopathic pulmonary fibrosis.

ABSTRACT:

Objectives

Evaluation and follow-up of idiopathic pulmonary fibrosis (IPF) mainly rely on high-resolution computed tomography (HRCT) and pulmonary function tests (PFTs). The elastic registration technique can quantitatively assess lung shrinkage. We aimed to investigate the correlation between lung shrinkage and morphological and functional deterioration in IPF.

Methods

Patients with IPF who underwent at least two HRCT scans and PFTs were retrospectively included. Elastic registration was performed on the baseline and follow-up HRCTs to obtain deformation maps of the whole lung. Jacobian determinants were calculated from the deformation fields and after logarithm transformation, log_jac values were represented on color maps to describe morphological deterioration, and to ass

SUBMITTER: Sun H 

PROVIDER: S-EPMC10017651 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature