Prenatal exposure to concentrated ambient PM_2.5 results in spatial memory defects regulated by DNA methylation in male mice offspring.

ABSTRACT: Ambient fine particulate matter (PM_2.5) exposures during pregnancy could lead to adverse birth outcomes, including neurobehavioral development defects. However, limited studies explored the effects and potential epigenetic mechanisms of maternal PM_2.5 exposure on offspring spatial memory defects. This study aims to explore the effects and underlying epigenetic mechanisms of maternal concentrated ambient PM_2.5 exposure in male mice offspring with spatial memory defects. Pregnant female C57BL/6 mice were exposed daily to concentrated ambient PM_2.5 (CAP) or filtered air (FA) throughout gestation, with the concentration of particulates (102.99 ± 78.74 μg/m³) and (2.78 ± 1.19 μg/m³), respectively. Adult male mice offspring were s

SUBMITTER: Yang Y 

PROVIDER: S-EPMC10017658 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature