CD115^- monocytic myeloid-derived suppressor cells are precursors of OLFM4^high polymorphonuclear myeloid-derived suppressor cells.

ABSTRACT: Myeloid-derived suppressor cells (MDSCs) consist of monocytic (M-) MDSCs and polymorphonuclear (PMN-) MDSCs that contribute to an immunosuppressive environment in tumor-bearing hosts. However, research on the phenotypic and functional heterogeneity of MDSCs in tumor-bearing hosts and across different disease stage is limited. Here we subdivide M-MDSCs based on CD115 expression and report that CD115^- M-MDSCs are functionally distinct from CD115⁺ M-MDSCs. CD115^- M-MDSCs increased in bone marrow and blood as tumors progressed. Transcriptome analysis revealed that CD115^- M-MDSCs expressed higher levels of neutrophil-related genes. Moreover, isolated CD115^- M-MDSCs had higher potential to be differentiated into PMN-MDSCs compared with CD115

SUBMITTER: Zou Y 

PROVIDER: S-EPMC10017706 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature