High prevalence of fluconazole resistant Candida tropicalis among candiduria samples in China: An ignored matter of concern.

ABSTRACT:

Introduction

The rapid rise of azole resistance in Candida tropicalis causing invasive infections has become a public health concern; however, the prevalence of resistant isolates in urine samples was not well studied, because the clinical significance of candiduria was not unambiguous due to possible host colonization.

Methods

We performed a 12-year laboratory-based surveillance study of C. tropicalis causing either invasive infection or candiduria and studied their susceptibility profiles to common antifungal drugs. The complete coding domain sequence of the ERG11 gene was amplified in all fluconazole resistant isolates, and aligned with the wild-type sequence to detect nucleotide mutations.

Results

A total of 519 unique C. tropicalis str

SUBMITTER: Fan X 

PROVIDER: S-EPMC10017723 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature