Nondestructive label-free detection of peritumoral white matter damage using cross-polarization optical coherence tomography.

ABSTRACT:

Introduction

To improve the quality of brain tumor resections, it is important to differentiate zones with myelinated fibers destruction from tumor tissue and normal white matter. Optical coherence tomography (OCT) is a promising tool for brain tissue visualization and in the present study, we demonstrate the ability of cross-polarization (CP) OCT to detect damaged white matter and differentiate it from normal and tumor tissues.

Materials and methods

The study was performed on 215 samples of brain tissue obtained from 57 patients with brain tumors. The analysis of the obtained OCT data included three stages: 1) visual analysis of structural OCT images; 2) quantitative assessment based on attenuation coefficients estimation in co- and cross-polarizations; 3) building of color

SUBMITTER: Achkasova KA 

PROVIDER: S-EPMC10017731 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature