Individualized network analysis: A novel approach to investigate tau PET using graph theory in the Alzheimer's disease continuum.

ABSTRACT:

Introduction

Tau PET imaging has emerged as an important tool to detect and monitor tangle burden in vivo in the study of Alzheimer's disease (AD). Previous studies demonstrated the association of tau burden with cognitive decline in probable AD cohorts. This study introduces a novel approach to analyze tau PET data by constructing individualized tau network structure and deriving its graph theory-based measures. We hypothesize that the network- based measures are a measure of the total tau load and the stage through disease.

Methods

Using tau PET data from the AD Neuroimaging Initiative from 369 participants, we determine the network measures, global efficiency, global strength, and limbic strength, and compare with two regional measures entorhinal and tau composite SUVR, i

SUBMITTER: Protas H 

PROVIDER: S-EPMC10017746 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature