Dietary protection against the visual and motor deficits induced by experimental autoimmune encephalomyelitis.

ABSTRACT:

Introduction

Five to eight percent of the world population currently suffers from at least one autoimmune disorder. Despite multiple immune modulatory therapies for autoimmune demyelinating diseases of the central nervous system, these treatments can be limiting for subsets of patients due to adverse effects and expense. To circumvent these barriers, we investigated a nutritional intervention in mice undergoing experimental autoimmune encephalomyelitis (EAE), a model of autoimmune-mediated demyelination that induces visual and motor pathologies similar to those experienced by people with multiple sclerosis (MS).

Methods

EAE was induced in female and male mice and the impact of limiting dietary carbohydrates by feeding a ketogenic diet (KD) enriched in medium chain triglyceri

SUBMITTER: Zyla-Jackson K 

PROVIDER: S-EPMC10017782 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature