Calcinosis in juvenile dermatomyositis: Updates on pathogenesis and treatment.

ABSTRACT: Calcinosis, or the deposition of insoluble calcium salts in the skin, subcutaneous tissue, fascia, tendons, and muscles, is a feared complication of juvenile dermatomyositis. Calcinosis is estimated to affect up to 40% of patients with juvenile dermatomyositis and contributes to significant disease morbidity. Calcinosis can be challenging to treat, and the most effective treatment remains unknown because of a lack of comparative studies. We aim to review the literature published in the last 5 years to summarize updates on the pathogenesis and treatment of calcinosis in juvenile dermatomyositis and describe future areas for research.

SUBMITTER: Pinotti CS 

PROVIDER: S-EPMC10017873 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature