Previous corticosteroid exposure associates with an increased Pneumocystis jirovecii pneumonia mortality among HIV-negative patients: a global research network with a follow-up multicenter case-control study.

ABSTRACT:

Background

HIV-negative patients have substantial mortality from Pneumocystis jirovecii pneumonia (PJP). We lack predictors of HIV-negative PJP-associated mortality.

Objective

We aim to characterize the role of prior corticosteroid exposure in PJP-related mortality.

Methods

We queried a global research network to identify adult HIV-negative patients with PJP with or without corticosteroid exposure in the preceding year before diagnosis (n = 8,021). We performed a propensity score-matched analysis to adjust baseline patient characteristics and analyzed outcomes. We follow-up the results with a multicenter ten years retrospective case-control cohort of HIV-negative patients tested for PJP by PCP Direct Fluorescent Antigen. We used a Cox proportional hazard

SUBMITTER: Vargas Barahona L 

PROVIDER: S-EPMC10017958 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature