Extending the dosing interval of COVID-19 vaccination leads to higher rates of seroconversion in people living with HIV.

ABSTRACT:

Introduction

Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is an effective way of protecting individuals from severe coronavirus disease 2019 (COVID-19). However, immune responses to vaccination vary considerably. This study dynamically assessed the neutralizing antibody (NAb) responses to the third dose of the inactivated COVID-19 vaccine administered to people living with human immunodeficiency virus (HIV; PLWH) with different inoculation intervals.

Methods

A total of 171 participants were recruited: 63 PLWH were placed in cohort 1 (with 3-month interval between the second and third doses), while 95 PLWH were placed in cohort 2 (with 5-month interval between the second and third doses); 13 individuals were enrolled as healthy co

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10017959 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature