Meteorin-like levels are associated with active brown adipose tissue in early infancy.

ABSTRACT:

Introduction

Meteorin-like (METRNL) is a hormonal factor released by several tissues, including thermogenically active brown and beige adipose tissues. It exerts multiple beneficial effects on metabolic and cardiovascular systems in experimental models. However, the potential role of METRNL as brown adipokine in humans has not been investigated previously, particularly in relation to the metabolic adaptations taking place in early life, when brown adipose tissue (BAT) is particularly abundant.

Methods and materials

METRNL levels, as well as body composition (DXA) and circulating endocrine-metabolic variables, were assessed longitudinally in a cohort of infants at birth, and at ages 4 and 12 months. BAT activity was measured by infrared thermography at age 12 months. METRNL l

SUBMITTER: Garcia-Beltran C 

PROVIDER: S-EPMC10018039 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature